Artichoke Spinach Grilled Cheese

Featured in: Weekend Homestyle Favorites

This decadent grilled cheese sandwich combines a savory spinach-artichoke filling with melted cheese between crispy sourdough slices. The filling blends cream cheese, mozzarella, Monterey Jack, and Parmesan with fresh spinach and artichoke hearts, seasoned with garlic and a hint of red pepper for depth. Simply spread the mixture onto bread, butter the outside, and pan-fry until golden and melty. Perfect served alongside tomato soup or a fresh salad, this vegetarian main is ready in just 25 minutes and serves four.

Updated on Tue, 20 Jan 2026 16:36:00 GMT
Golden brown sourdough slices sandwich melted spinach and artichoke dip filling. Pin It
Golden brown sourdough slices sandwich melted spinach and artichoke dip filling. | sweetcairn.com

The smell of butter melting into sourdough takes me back to late nights when my roommate and I would invent sandwiches after studying. This one started as a joke—what if we put that party dip everyone loves inside grilled cheese—and somehow it became the most requested comfort food in our apartment. Now every time I make it, I remember how simple ingredients can surprise you.

Last winter my sister came over exhausted after a 12 hour shift and I made these for us. She took one bite and actually stopped talking for a full minute, which never happens. Now she calls them therapy sandwiches whenever life gets overwhelming.

Ingredients

  • Fresh spinach: Use fresh and chop it yourself if possible, but frozen works perfectly if you thaw and squeeze out all the excess water first
  • Artichoke hearts: Canned or jarred both work, just make sure they are well drained so your filling does not get watery
  • Cream cheese: Room temperature cream cheese blends smoothly into the other cheeses and helps hold everything together
  • Mozzarella and Monterey Jack: This combination gives you the perfect balance of melt and mild flavor without overpowering the vegetables
  • Parmesan: Adds a salty umami punch that makes the filling taste much more complex than it actually is
  • Sourdough bread: The sturdy texture holds up to the generous filling and develops the best crunch when buttered and grilled
  • Garlic: Fresh minced garlic adds a sharp bite that cuts through all the rich cheese
  • Black pepper and red pepper flakes: Just enough heat to make things interesting without overwhelming the creamy filling
  • Unsalted butter: Softened butter spreads evenly and helps the bread achieve that golden restaurant quality exterior

Instructions

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Mix the filling:
Combine all the cheeses, spinach, artichokes, garlic, and seasonings in a bowl until everything is evenly distributed and creamy
Assemble the sandwiches:
Spread a generous layer of the filling onto four slices of bread, then top with the remaining slices to close them up
Butter the bread:
Spread softened butter on the outside of each sandwich, covering the entire surface for even browning
Grill to perfection:
Cook in a hot skillet over medium heat for 3 to 4 minutes per side, pressing gently, until the bread turns golden brown and crispy
Rest and serve:
Let the sandwiches sit for about a minute so the filling sets slightly, then slice diagonally and serve while still hot
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The Artichoke Spinach Grilled Cheese features a creamy, bubbly interior and crisp buttered crust. Pin It
The Artichoke Spinach Grilled Cheese features a creamy, bubbly interior and crisp buttered crust. | sweetcairn.com

These have become my go to when friends need cheering up or when rain keeps everyone inside. Something about warm melted cheese and tender artichokes feels like a hug in sandwich form.

Choosing the Right Bread

Sourdough works best because the tangy flavor complements the rich filling and the structure stands up to grilling. If you need to substitute, choose a hearty bread that will not fall apart when loaded with cheese.

Make Ahead Strategies

The filling keeps beautifully in the refrigerator for up to two days, so you can mix everything on Sunday and have quick sandwiches ready to grill all week long. Just let it come to room temperature for easier spreading.

Serving Suggestions

These are substantial enough to stand alone, but a simple tomato soup or crisp green salad makes the meal feel complete. The acidity of tomatoes cuts through all that richness beautifully.

  • Try adding sun dried tomatoes to the filling for extra depth
  • Whole wheat bread adds fiber and a nutty flavor
  • Leftover filling works wonderfully stuffed inside chicken breasts
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Served on a cutting board, perfect for pairing with tomato soup. Pin It
Served on a cutting board, perfect for pairing with tomato soup. | sweetcairn.com

Hope this brings as much comfort to your kitchen as it has to mine over the years.

Recipe FAQs

Can I prepare this sandwich ahead of time?

Yes, you can prepare the artichoke-spinach filling up to 2 days in advance and store it in the refrigerator. Assemble and cook the sandwiches when ready to serve for best results with crispy bread and melted cheese.

What type of bread works best?

Sourdough bread is recommended for its tangy flavor and sturdy texture that holds up well to the moist filling and grilling process. Whole wheat bread adds fiber, while gluten-free options work for dietary needs.

How do I prevent the filling from leaking out?

Spread the artichoke-spinach mixture evenly, avoiding the bread edges. Don't overfill the sandwich, and press gently while cooking. Letting the sandwich rest for 1 minute after cooking helps the cheese set before slicing.

What variations can enhance the filling?

Stir in sun-dried tomatoes for sweetness, add chopped scallions for fresh onion notes, or include fresh basil for herbaceous flavor. A pinch of nutmeg complements the spinach beautifully.

What temperature should the skillet be?

Medium heat is ideal to allow the cheese to melt thoroughly while the bread achieves a golden, crispy exterior without burning. This takes approximately 3-4 minutes per side depending on bread thickness and skillet hotness.

Is this sandwich suitable for vegetarians?

Yes, this sandwich is completely vegetarian, using only plant-based vegetables and dairy products. It's an excellent meatless main dish option that's satisfying and flavorful.

Artichoke Spinach Grilled Cheese

Creamy spinach-artichoke dip meets golden sourdough in this indulgent grilled cheese sandwich.

Prep Duration
15 minutes
Time to Cook
10 minutes
Time Needed
25 minutes
Recipe by Hunter Phillips


Level Easy

Cuisine American

Makes 4 Portions

Dietary Notes Suitable for Vegetarians

Ingredient List

Vegetables

01 1 cup fresh spinach, chopped
02 1 cup canned or jarred artichoke hearts, drained and chopped

Dairy

01 4 oz cream cheese, softened
02 1/2 cup shredded mozzarella cheese
03 1/2 cup shredded Monterey Jack or Swiss cheese
04 1/4 cup grated Parmesan cheese
05 2 tablespoons unsalted butter, softened

Bread

01 8 slices sourdough bread

Seasonings

01 1 small garlic clove, minced
02 1/4 teaspoon black pepper
03 1/8 teaspoon crushed red pepper flakes
04 Pinch of salt

Steps

Step 01

Prepare the filling: In a mixing bowl, combine cream cheese, mozzarella, Monterey Jack or Swiss cheese, Parmesan, spinach, artichokes, garlic, black pepper, red pepper flakes, and salt. Mix until well blended.

Step 02

Assemble sandwiches: Lay out the sourdough slices. Spread the artichoke-spinach mixture evenly onto 4 slices. Top with remaining bread slices to form sandwiches.

Step 03

Butter the exterior: Lightly butter the outside of each sandwich on both sides.

Step 04

Cook the sandwiches: Heat a large skillet or griddle over medium heat. Place sandwiches in the pan and cook 3 to 4 minutes per side, pressing gently, until bread is golden brown and cheese is melted.

Step 05

Rest and serve: Remove from skillet, let rest 1 minute, then slice and serve warm.

Equipment Needed

  • Mixing bowl
  • Spoon or spatula
  • Knife and cutting board
  • Skillet or griddle
  • Spatula for flipping

Allergy Info

Look through each ingredient for allergens and check with a healthcare provider if you’re uncertain.
  • Contains dairy: cheese and butter
  • Contains wheat in bread
  • May contain soy depending on bread and cheese brands

Nutrition Info (each serving)

Figures are for reference only—always seek medical advice when needed.
  • Caloric Value: 410
  • Fats: 23 grams
  • Carbohydrates: 38 grams
  • Proteins: 15 grams